The nephroprotective effects of Daucus carota and Eclipta prostrata against cisplatin-induced nephrotoxicity in rats
| Autor: | Muhammad Omer Iqbal, Asad Saleem Sial, Imran Akhtar, Muhammad Naeem, Abu Hazafa, Rais A. Ansari, Syed A. A. Rizvi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Urination cisplatin Bioengineering Kidney Protective Agents Applied Microbiology and Biotechnology Animals Rats Wistar nephroprotection Plant Extracts nephrotoxicity Body Weight Sodium Eclipta Organ Size General Medicine daucus carota eclipta prostrata rats Creatinine Potassium Kidney Diseases TP248.13-248.65 Research Article Research Paper Biotechnology |
| Zdroj: | Bioengineered, Vol 12, Iss 2, Pp 12702-12721 (2021) Bioengineered article-version (VoR) Version of Record |
| ISSN: | 2165-5987 2165-5979 |
| Popis: | The overuse of cisplatin (>50 mg/m2) is limited to nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. The objective of this study was to investigate the nephroprotective effects of Daucus carota and Eclipta prostrata extracts on cisplatin-induced nephrotoxicity in Wistar albino rats. The study involved male Wistar albino rats of 8 weeks weighing 220–270 g. A single injection of 5 mg/kg was injected into the rats for nephrotoxicity. Rats were divided into four groups based on dose conentrations. Blood and urine samples of rats were collected on the 0, 7th, 14th, and 21st days for nephrological analysis. The results showed that Cis + DC/Cis + EP (600 mg/kg) significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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