Capecitabine for 5-Fluorouracil-Resistant Brain Metastases From Breast Cancer
| Autor: | Donald F. Schomer, Richard L. Theriault, W. K. A. Yung, Michael L. H. Wang, Melanie E. Royce |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Oncology Antimetabolites Antineoplastic Cancer Research medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Deoxycytidine Metastasis Capecitabine chemistry.chemical_compound Breast cancer Internal medicine medicine Humans Prodrugs Chemotherapy Performance status Brain Neoplasms business.industry medicine.disease Magnetic Resonance Imaging Surgery chemistry Drug Resistance Neoplasm Fluorouracil Female business medicine.drug Brain metastasis |
| Zdroj: | American Journal of Clinical Oncology. 24:421-424 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/00000421-200108000-00026 |
| Popis: | We report a case in which brain metastases originating from breast cancer responded to treatment with oral capecitabine. The metastases had progressed and Karnofsky performance status deteriorated despite whole brain irradiation, hormonal treatment, and systemic chemotherapy that included 5-fluorouracil (5-FU). In contrast, 2 months of treatment with oral capecitabine produced a partial response, documented by lesion size on magnetic resonance imaging and an improvement in performance status; both measures continued to improve during 11 months of capecitabine treatment. |
| Databáze: | OpenAIRE |
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