Tolerability and surrogate efficacy parameters of a polymerized depot mixture pollen extracts without dilutional effect
| Autor: | María Angeles Lara, Gemma Vanesa Sánchez, L. Begona, Juan A. Asturias, Alberto Martínez, Joaquín Quiralte, Carmen Arilla, Javier Monteserín, Begoña Madariaga, María Cruz Gómez-Fernández, Luis Andrés López Fernández |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Immunoglobulin levels Depot Specific immunoglobulin E Immunology Infusions Subcutaneous Gastroenterology Polymerization Phleum Young Adult 03 medical and health sciences 0302 clinical medicine Clinical Protocols Olea Internal medicine Immune Tolerance medicine Subcutaneous immunotherapy Humans Immunology and Allergy biology Plant Extracts business.industry Rhinitis Allergic Seasonal Allergens Immunoglobulin E Middle Aged biology.organism_classification Asthma Systemic reaction 030104 developmental biology 030228 respiratory system Oncology Tolerability Desensitization Immunologic Pollen Female business Pollen extracts |
| Zdroj: | Immunotherapy. 11:1031-1042 |
| ISSN: | 1750-7448 1750-743X |
| DOI: | 10.2217/imt-2019-0051 |
| Popis: | Aim: To evaluate tolerability of subcutaneous immunotherapy, in a polymerized mixture ( Olea europaea/ Phleum pratense) depot presentation. Patients & methods: A total of 47 poly-allergic patients received: an abbreviated schedule with three injections at weekly intervals or a cluster schedule with two administrations in 1 day. Both treatments continued with 3 monthly maintenance administrations. Results: Two systemic reactions, (4.3%). One grade 0 and one grade I. No local reactions. Immunoglobulin levels, increased significantly at final visit versus baseline in sIgG and sIgG4; in both schedules and allergens, no significant changes in specific immunoglobulin E levels were detected. Cutaneous reactivity at final visit decreased significantly. Conclusion: Both administration schedules with polymerized mixture of O. europaea/ P. pratense, presented an excellent tolerability profile and induced preliminary efficacy changes. |
| Databáze: | OpenAIRE |
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