Randomized trial of topical periocular castor oil treatment for blepharitis
| Autor: | Michael T.M. Wang, Jennifer P. Craig, Grant A. Watters, Marna Claassen, Emma C Sandford, Alice K. Jackson, Lauren Curd, Alex Muntz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Castor Oil business.product_category Adolescent Meibomian gland law.invention 03 medical and health sciences Young Adult 0302 clinical medicine Randomized controlled trial law medicine Humans Prospective Studies Blepharitis Telangiectasia biology business.industry Eyelids Madarosis Middle Aged biology.organism_classification medicine.disease Dermatology eye diseases Ophthalmology medicine.anatomical_structure Tears 030221 ophthalmology & optometry Female sense organs Eyelid medicine.symptom Eyelash business 030217 neurology & neurosurgery Demodex |
| Zdroj: | The ocular surface. 19 |
| ISSN: | 1937-5913 |
| Popis: | To evaluate the effects of topical castor oil application to the eyelids on ocular surface and tear film parameters in patients with blepharitis.Twenty-six participants (14 females, 12 males; mean ± SD age, 38 ± 21 years) with clinical signs of blepharitis were enrolled in a prospective, investigator-masked, randomized, paired-eye trial. A 100% cold pressed castor oil formulation (Lotus Garden Botanicals, Biddeford, ME, USA) was applied to the eyelids of one eye (randomized), twice daily for 4 weeks. Ocular surface characteristics, symptoms, and tear film parameters were assessed at baseline and day 28.Baseline measurements did not differ between treated and control eyes (all p 0.05). A significant reduction in OSDI symptomology score was observed following the four-week treatment period (p = 0.001). Clinical improvements in eyelid margin thickening, telangiectasia, eyelash matting, madarosis, cylindrical dandruff, and lid wiper epitheliopathy were limited to treated eyes (all p 0.01), while greater decreases in staphylococcal and seborrheic eyelash crusting were observed in treated than control eyes (both p 0.05). No adverse events were reported during the treatment period.Topical castor oil application effected significant improvements in ocular surface signs and symptoms in patients with blepharitis. The favourable therapeutic profile would suggest that castor oil demonstrates promise as a potential treatment for blepharitis, and support the conduct of further efficacy trials with longer follow up.ACTRN12618000856213. |
| Databáze: | OpenAIRE |
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