Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis
| Autor: | Claudio Gustavo Barbeito, Adriana Raquel Massone, Berenice Liyare Sanz Ressel |
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| Rok vydání: | 2020 |
| Předmět: |
Skin Neoplasms
Carcinogenesis 040301 veterinary sciences Cutaneous papilloma Biology 0403 veterinary science 03 medical and health sciences Dogs Expression pattern Animals Dog Diseases Adaptor Proteins Signal Transducing 030304 developmental biology 0303 health sciences Tissue microarray Papilloma General Veterinary Epidermis (botany) Effector Gene Expression Profiling 04 agricultural and veterinary sciences Hedgehog signaling pathway Tissue Array Analysis Carcinoma Squamous Cell Cancer research Molecular mechanism Immunohistochemistry Epidermis Signal Transduction |
| Zdroj: | Research in Veterinary Science. 130:93-97 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2020.03.006 |
| Popis: | Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis process could be the basis for the development of novel molecular mechanism-based antitumour treatments for CP and CSCC canine patients. Recent evidence suggests that the development and progression of CP and CSCC involve the dysregulated activation of the Hippo signalling pathway effector YAP. Thus, in the present study, we evaluated the immunohistochemical expression pattern of YAP in sections of tissue microarrays constructed from canine samples of normal epidermis, CP, preneoplastic epidermis, and CSCC. In samples of CP, preneoplastic epidermis, and CSCC, YAP expression was significantly increased relative to normal epidermis. This emerging evidence suggests that the dysregulated activity of the Hippo signalling pathway effector YAP represents a frequent event during canine epidermal tumourigenesis, pointing to this protein as a potential therapeutic target for the treatment of CP and CSCC in dogs. |
| Databáze: | OpenAIRE |
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