Blood-glucose, plasma-insulin and growth hormone concentrations of individuals with minor abnormalities of glucose tolerance
| Autor: | F. L. Mitchell, W. T. Strauss, C. N. Hales, F. C. Greenwood |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Group ii Blood sugar Endogeny Biology Growth hormone Prediabetic State Sex Factors Glycosuria Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Humans Insulin Obesity Child Glucose plasma Aged Age Factors Glucose Tolerance Test Middle Aged medicine.disease Endocrinology Growth Hormone Female Insulin Resistance Plasma insulin |
| Zdroj: | Diabetologia. 4:73-82 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/bf01212536 |
| Popis: | 1. The blood-glucose, plasma insulin and growth hormone concentrations have been measured in the fasting state and 30, 60, 90 and 120 min after 50 g glucose administered orally to three groups of subjects: Group I — normal glucose tolerance, no glucosuria; Group II — normal glucose tolerance and glucosuria, Group III — normal fasting blood-sugar concentration but a failure of the blood sugar to return to the fasting level up to 120 min after glucose. — 2. The influence of weight, sex and age on the results has been analysed. The need for careful matching of subjects with respect to weight, sex and age in a study of changes in blood-glucose, plasma-insulin and growth hormone concentration is emphasized. — 3. The blood-glucose and plasma-insulin concentrations observed in Group II were characterized by an exaggerated early rise and a tendency to late hypoglycaemia. Additional abnormalities were present in this group. — 4. The non-obese subjects of Group III showed a delay in the rise of plasma insulin concentration following oral glucose and some evidence of resistance to endogenous insulin. The relevance of these findings to the aetiology of diabetes mellitus is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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