The structure and function of initiation factors in eukaryotic protein synthesis
| Autor: | T. V. Pestova, C. U. T. Hellen |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Molecular Sequence Data
Biology Cellular and Molecular Neuroscience Peptide Initiation Factors Eukaryotic initiation factor Animals Humans Initiation factor Amino Acid Sequence Peptide Chain Initiation Translational Molecular Biology Prokaryotic initiation factor Pharmacology Genetics eIF2 Prokaryotic initiation factor-2 Prokaryotic initiation factor-1 Cell Biology EIF4A1 Cell biology Internal ribosome entry site Eukaryotic Cells RNA Ribosomal Protein Biosynthesis Molecular Medicine Ribosomes |
| Zdroj: | Cellular and Molecular Life Sciences. 57:651-674 |
| ISSN: | 1420-682X |
| DOI: | 10.1007/pl00000726 |
| Popis: | Protein synthesis is one of the most complex cellular processes, involving numerous translation components that interact in multiple sequential steps. The most complex stage in protein synthesis is the initiation process. It involves initiation factor-mediated assembly of a 40S ribosomal subunit and initiator tRNA into a 48S initiation complex at the initiation codon of an mRNA and subsequent joining of a 60S ribosomal subunit to form a translationally active 80S ribosome. The basal set of factors required for translation initiation has been determined, and biochemical, genetic, and structural studies are now beginning to reveal details of their individual functions in this process. The mechanism of translation initiation has also been found to be influenced significantly by structural properties of the 5' and 3' termini of individual mRNAs. This review describes some of the major developments in elucidating molecular details of the mechanism of initiation that have occurred over the last decade. |
| Databáze: | OpenAIRE |
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