Oviductal Telocytes in Patients with Uterine Myoma
| Autor: | Krzysztof Gil, Veronika Aleksandrovych, Kazimierz Pityński, Tomasz Bereza, Anna Natalia Wrona |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Infertility
Pathology medicine.medical_specialty PDGFRα oviduct QH301-705.5 Population Medicine (miscellaneous) Context (language use) telocytes muscular contractility Article General Biochemistry Genetics and Molecular Biology Contractility medicine Biology (General) education education.field_of_study business.industry Cilium Tubal factor infertility medicine.disease Oviduct Immunohistochemistry CD34 business infertility |
| Zdroj: | Biomedicines, Vol 9, Iss 1060, p 1060 (2021) Biomedicines Volume 9 Issue 8 |
| ISSN: | 2227-9059 |
| Popis: | Tubal factor infertility occurs in 30–35% of infertile pairs and may be caused by impaired muscular contractility and ciliary beating as well as immunological imbalance and chronic inflammation. Newly discovered telocytes (TCs) have a wide palette of features, which play a role in oviduct physiology. We have observed tissue samples from human fallopian tubes in patients with and without uterine myoma by immunolabelling. According to the immunohistochemical co-expression of markers, it has been determined that TCs are engaged in a wide range of physiological processes, including local innervation, sensitivity to hypoxia, regulation of calcium, and sex steroid hormones balances. Due to the proximity of NOS- and ChAT-positive nerve fibers and the expression of ion channels markers, tubal TCs might be considered conductor cells. Additionally, their integration in contractions and cilia physiology in the context of fertility has been revealed. We have observed the difference in telocytes expression in the human oviduct between groups of patients and attempted to describe this population of cells specifically in the case of infertility development, a clinically relevant avenue for further studies. |
| Databáze: | OpenAIRE |
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