Identification of characteristic subepithelial surface granulomatosis in immune‐related adverse event‐associated enterocolitis
| Autor: | Tadashi Hasegawa, Mayuko Akimoto, Yoshihiko Hirohashi, Noriaki Kikuchi, Tomoki Kikuchi, Tatsuru Ikeda, Kiyoshi Kasai, Terufumi Kubo, Yasuhiro Kikuchi, Tomoyo Shinkawa, Kenji Murata, Hiroyuki Iwaki, Yoshiko Keira, Toshihiko Torigoe, Tomohide Tsukahara, Masahiko Obata, Keiko Segawa, Rena Morita, Takayuki Kanaseki |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Cancer Research medicine.medical_specialty Exacerbation Colon colitis Biopsy Gastroenterology immune checkpoint inhibitors 03 medical and health sciences 0302 clinical medicine Immune system Neoplasms Report Internal medicine Humans Medicine Intestinal Mucosa Colitis Adverse effect Prospective cohort study Aged Retrospective Studies Aged 80 and over Enterocolitis business.industry subepithelial surface granulomatosis General Medicine Middle Aged medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis biomarker Biomarker (medicine) Female Histopathology medicine.symptom business immune‐related adverse event Reports |
| Zdroj: | Cancer Science |
| ISSN: | 1349-7006 1347-9032 |
| DOI: | 10.1111/cas.14773 |
| Popis: | Immune checkpoint inhibitors (ICIs) have provided an additional treatment option for various types of human cancers. However, ICIs often induce various immune‐related adverse events (irAEs). Enterocolitis is a major irAE with poorly understood histopathological characteristics. In this study, we retrospectively investigated the histopathology of colon tissue samples from 17 patients treated with ICIs. There were two major histological patterns of colitis: an ulcerative colitis‐like pattern and a graft vs host disease‐like pattern. Although these two patterns of colitis were mutually exclusive, both patterns often showed a characteristic that we call “subepithelial surface granulomatosis” (SSG), which has not been reported in other types of colitis. SSG was found even in colon tissue without symptoms or endoscopic findings of colitis. Given the increasing reports of sarcoid reaction or exacerbation of tuberculosis after treatment with ICIs, granuloma formation could be a histological hallmark of systemic immune activation by ICIs. Although statistical significance was not obtained, probably because of the small sample size, SSG may be a surrogate biomarker of systemic anticancer immune activation. We propose that a prospective study with larger sample size be performed. In this study, we retrospectively investigated the histopathology of colon tissue samples from 17 patients treated with immune checkpoint inhibitors. Interestingly, we found characteristic “subepithelial surface granulomatosis” (SSG) in the colon tissue. Although statistical significance was not obtained, probably because of the small sample size, SSG may be a surrogate biomarker of systemic anti‐cancer immune activation. |
| Databáze: | OpenAIRE |
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