Viral sequence diversity: challenges for AIDS vaccine designs
| Autor: | Ted M. Ross, Sean P. McBurney |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
media_common.quotation_subject
Immunology HIV Infections Article Immune system Viral sequence Viral envelope Acquired immunodeficiency syndrome (AIDS) Drug Discovery medicine Humans media_common AIDS Vaccines Pharmacology chemistry.chemical_classification Polymorphism Genetic biology env Gene Products Human Immunodeficiency Virus biology.organism_classification medicine.disease Virology chemistry Lentivirus HIV-1 Molecular Medicine Glycoprotein Diversity (politics) |
| Zdroj: | Expert Review of Vaccines. 7:1405-1417 |
| ISSN: | 1744-8395 1476-0584 |
| DOI: | 10.1586/14760584.7.9.1405 |
| Popis: | Among the greatest challenges facing AIDS vaccine development is the intrinsic diversity among circulating populations of HIV-1 in various geographical locations and the need to develop vaccines that can elicit enduring protective immunity to variant HIV-1 strains. While variation is observed in all of the viral proteins, the greatest diversity is localized to the viral envelope glycoproteins, evidently reflecting the predominant role of these proteins in eliciting host immune recognition and responses that result in progressive evolution of the envelope proteins during persistent infection. Interestingly, while envelope glycoprotein variation is widely assumed to be a major obstacle to AIDS vaccine development, there is very little experimental data in animal or human lentivirus systems addressing this critical issue. In this review, the state of vaccine development to address envelope diversity will be presented, focusing on the use of centralized and polyvalent sequence design as mechanisms to elicit broadly reactive immune responses. |
| Databáze: | OpenAIRE |
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