Age-changes in right ventricular function–pulmonary circulation coupling: from pediatric to adult stage in 1899 healthy subjects. The RIGHT Heart International NETwork (RIGHT-NET)
| Autor: | Marco Guazzi, Francesco Bandera, Olga Vriz, Luna Gargani, Antonio Cittadini, Alberto M. Marra, Ekkehard Grünig, Antonello D'Andrea, Gergely Ágoston, Brigida Ranieri, Gruschen Veldman, Sarah Aldosari Radaan, Rosangela Cocchia, Damien Voilliot, Lawrence G. Rudski, Francesco Ferrara, Anna Agnese Stanziola, Andrea Salzano, Jarosław D. Kasprzak, Eduardo Bossone, Paolo Frumento, Michele D'Alto, Filippo Cademartiri |
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| Přispěvatelé: | Vriz, O., Veldman, G., Gargani, L., Ferrara, F., Frumento, P., D'Alto, M., D'Andrea, A., Radaan, S. A., Cocchia, R., Marra, A. M., Ranieri, B., Salzano, A., Stanziola, A. A., Voilliot, D., Agoston, G., Cademartiri, F., Cittadini, A., Kasprzak, J. D., Grunig, E., Bandera, F., Guazzi, M., Rudski, L., Bossone, E. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pulmonary Circulation Ventricular Dysfunction Right Predictive Value of Test Right ventricular–arterial coupling Normal subjects 80 and over Ventricular Dysfunction Ventricular Function Child Body surface area Aged 80 and over Ventricular function Healthy subjects Stroke volume Middle Aged Healthy Volunteer Healthy Volunteers Tricuspid annular plane systolic excursion Right Echocardiography Child Preschool Cardiology Female Cardiology and Cardiovascular Medicine Pulmonary artery systolic pressure Human Adolescent Adult Aged Humans Infant Predictive Value of Tests Stroke Volume Young Adult Ventricular Function Right medicine.medical_specialty Internal medicine medicine.artery Heart rate medicine Radiology Nuclear Medicine and imaging Preschool Age changes business.industry Normal subject stomatognathic diseases Right heart Pulmonary artery business |
| Popis: | The present study analyzes age-specific changes in RV function and RV-PA coupling in a large cohort of apparently healthy subjects with a wide age-range, to identify reference values and to study the influence of clinical and echocardiographic cofactors. 1899 Consecutive healthy subjects underwent a standardized transthoracic echocardiographic examination. Tricuspid annular plane systolic excursion (TAPSE) and systolic pulmonary artery pressure (SPAP) were measured. Ventriculo-arterial coupling was then inferred from the TAPSE/SPAP ratio. A quantile regression analysis was used to estimate quantiles 0.05, 0.10, 0.50 (median), 0.90, and 0.95 of TAPSE, SPAP and TAPSE/SPAP. The association between age and each of these values was determined. The mean age of the group was 45.2 ± 18.5 years (range 1 to 102 years), 971 were males. SPAP increased with age, whereas TAPSE and TAPSE/SPAP ratio decreased. Upon multivariate modeling, the most significant positive associations for TAPSE were body surface area (BSA) driven by the pediatric group, stroke volume (SV), E/A and negatively heart rate and E/e' ratio. SPAP was positively associated with increasing age, SV, E/A, E/e' and negatively with BSA. TAPSE/SPAP ratio was negatively associated with age, female sex, and E/e' and positively with BSA. A preserved relationship between TAPSE and SPAP was found across the different age groups. TAPSE, SPAP and TAPSE/SPAP demonstrate important trends and associations with advancing age, impaired diastolic function, affected by female sex and BSA However the relationship between TAPSE and SPAP is relatively well preserved across the age spectrum. |
| Databáze: | OpenAIRE |
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