Residual immune activation in HIV-Infected individuals expands monocytic-myeloid derived suppressor cells
| Autor: | Ankita Garg, Ritesh Singh, Jamie Barber, Suman Kumar Roy, Anuradha Gautam, Mouli Chakraborty, Indranil Halder |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Chemokine Immunology India CCL4 HIV Infections Biology Monocytes Article 03 medical and health sciences 0302 clinical medicine Immune system In vivo CXCL10 Humans Interleukin 8 Interleukin 6 Cells Cultured Interleukin-6 Myeloid-Derived Suppressor Cells Middle Aged United States Gastrointestinal Microbiome 030104 developmental biology Anti-Retroviral Agents biology.protein Myeloid-derived Suppressor Cell Disease Progression HIV-1 Female 030215 immunology |
| Zdroj: | Cell Immunol |
| ISSN: | 1090-2163 |
| Popis: | HIV-infected individuals on combined antiretroviral therapy (ART) with virologic suppression exhibit sustained immune dysfunction. Our recent work has highlighted that monocytic myeloid derived suppressor cells (M-MDSC) are elevated in these individuals and suppress immune responses. Factors responsible for M-MDSC expansion in vivo are unknown. Here we compared circulating frequency of M-MDSC in HIV-infected persons from the US and India where HIV subtype-B or –C predominate, respectively. We further investigated soluble mediators of residual immune activation in two cohorts and determined their correlation with M-MDSC expansion. Our findings show that M-MDSC are elevated and correlate with plasma levels of IL-6 in both cohorts. Chemokines CXCL10, CCL4 and CXCL8 were also elevated in HIV-infected individuals, but were not correlated with M-MDSC. These findings support that IL-6 is important in M-MDSC expansion which is independent of HIV subtype. |
| Databáze: | OpenAIRE |
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