Nosocomial spread of a Staphylococcus capitis strain with heteroresistance to vancomycin in a neonatal intensive care unit
| Autor: | Yvette J. Debets-Ossenkopp, Ruurd M. van Elburg, Erik Reinders, Christina M. J. E. Vandenbroucke-Grauls, Maria Kapi, Keiichi Hiramatsu, Wil C. van der Zwet, Paul H. M. Savelkoul |
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| Přispěvatelé: | Other departments, Medical Microbiology and Infection Prevention |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Microbiology (medical)
Neonatal intensive care unit Epidemiology Staphylococcus Population Staphylococcal infections law.invention Microbiology Sepsis Fatal Outcome law Intensive Care Units Neonatal medicine Humans education Antibacterial agent education.field_of_study Cross Infection biology Infant Newborn Vancomycin Resistance Staphylococcal Infections medicine.disease biology.organism_classification Intensive care unit DNA Fingerprinting Staphylococcus capitis Phenotype Vancomycin medicine.drug |
| Zdroj: | Journal of clinical microbiology, 40(7), 2520-2525. American Society for Microbiology |
| ISSN: | 0095-1137 |
| DOI: | 10.1128/jcm.40.7.2520-2525.2002 |
| Popis: | A premature infant in a neonatal intensive care unit (NICU) developed a bloodstream infection caused by coagulase-negative staphylococci (CoNS) sensitive to vancomycin. The infection persisted for 3 weeks, despite therapy with vancomycin and replacement of all intravenous catheters. The neonate died due to necrotizing enterocolitis which developed during the ongoing sepsis. We screened this strain and 216 other strains of CoNS from cultures of blood obtained from neonates between 1997 and 2000 for heteroresistance to vancomycin. Forty-eight isolates, including the strain that caused ongoing sepsis, proved heteroresistant. All isolates were identified as Staphylococcus capitis and were identical, just as their resistant stable subcolonies were, when they were genetically fingerprinted by amplified-fragment length polymorphism analysis. The heteroresistant phenotype of this endemic strain was confirmed by population analysis. We conclude that heteroresistance to vancomycin occurs in S. capitis and might be the cause of therapeutic failures in NICUs. Moreover, heteroresistant strains can become endemic in such units. |
| Databáze: | OpenAIRE |
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