The LDL-C/ApoB ratio predicts major cardiovascular events in patients with established atherosclerotic cardiovascular disease
| Autor: | Arthur Mader, Heinz Drexel, Berthold Moser, Alexander Vonbank, Daniela Zanolin-Purin, Barbara Larcher, Christoph H. Saely, Christine Heinzle |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Apolipoprotein B Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans Myocardial infarction Prospective cohort study Apolipoproteins B biology business.industry Cholesterol LDL Atherosclerosis medicine.disease 030104 developmental biology Diabetes Mellitus Type 2 chemistry Cardiovascular Diseases Low-density lipoprotein Cohort Cardiology biology.protein lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Body mass index Mace |
| Zdroj: | Atherosclerosis. 329:44-49 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2021.05.010 |
| Popis: | Background and aims The low density lipoprotein cholesterol to Apolipoprotein B (LDL-C/ApoB) ratio is a validated proxy for low density lipoprotein (LDL) particle size that can be easily calculated from a standard lipid/apolipoprotein profile. Whether it is predictive of cardiovascular events in patients with established atherosclerosis is not known and is addressed in the present investigation. Methods We determined the LDL-C/ApoB ratio in a cohort of 1687 subjects with established atherosclerosis. Prospectively, major cardiovascular events (MACE) including cardiovascular death, non-fatal myocardial infarction and non-fatal stroke were recorded over a period of 9.9 ± 4.6 years. The study covers >16,000 patient-years. Results At baseline, the LDL-C/ApoB ratio was 1.36 ± 0.28 in our cohort. During follow up, a total of 558 first MACE were recorded. The LDL-C/ApoB ratio predicted MACE in univariate Cox proportional hazard analysis (HR 0.90 [0.82–0.98]; p = 0.014); this finding was confirmed after adjustment for age, gender, intensity of statin treatment, hypertension, history of smoking, type 2 diabetes, body mass index and ApoB (HR 0.87 [0.78–0.97]; p = 0.013). Conclusions The LDL-C/ApoB ratio is independently predictive of MACE in subjects with established atherosclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect