Epidemiological, clinical, and biochemical characteristics of Saudi patients with nonalcoholic fatty liver disease: a hospital-based study
| Autor: | Alwaleed Alhammad, M. M. B. El-Sabbah, Mustafa Hussein Adam, Khalid Alswat, Safiyya Ali, Faisal M. Sanai, Mansour Altuwaijri, Waleed Al-Hamoudi, Mohamed Abdelmohsen Bedewi, Ayman A. Abdo |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Pathology education Saudi Arabia lcsh:Medicine Body Mass Index Diabetes Complications Hospitals University Hospital based study Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Diabetes mellitus parasitic diseases Nonalcoholic fatty liver disease Epidemiology medicine Humans Obesity Prospective Studies High prevalence business.industry lcsh:R Age Factors Alanine Transaminase General Medicine Middle Aged medicine.disease Fatty Liver Lipoproteins LDL Female Lipoproteins HDL business geographic locations |
| Zdroj: | Annals of Saudi Medicine, Vol 32, Iss 3, Pp 288-292 (2012) |
| ISSN: | 0975-4466 0256-4947 |
| DOI: | 10.5144/0256-4947.2012.288 |
| Popis: | BACKGROUND: The estimated prevalence of nonalcoholic fatty liver disease (NAFLD) in Saudi Arabia is 7% to 10%. Despite the high prevalence of risk factors including diabetes, obesity, and hyperlipidemia, no recent epidemiological studies have measured the disease burden. We aimed to determine the characteristics of Saudi NAFLD patients attending a university hospital, and study factors affecting alanine aminotransferase (ALT) levels. DESIGN AND SETTING: A prospective study among patients referred for ultrasonography in King Khalid University Hospital in Riyadh, Saudi Arabia from February to May 2009. PATIENTS AND METHODS: NAFLD was defined as an appearance of fatty liver on routine abdominal ultrasound in the absence of coexisting liver disease and alcohol consumption. Patients were classified into normal and high ALT (ALT >60 U/L) level groups for analysis. RESULTS: The prevalence of NAFLD was 16.6% (218/1312). Patients with normal ALT had the mean (SD) age of 45.9 (10.6) years and the mean body mass index of 34.5 (7.9) kg/m2. Forty percent of the 151 patients with normal ALT had diabetes, 66.2% were obese, and 29.1% had hypertension. Forty-three patients (23%) had high ALT levels. These patients had significantly lower age (P=.003) and fasting blood sugar (P=.03) than the normal ALT group. Non-diabetic patients (odds ratio 0.30, 95% CI 0.1-0.8), men (female OR 0.23, 95% CI 0.1-0.5), lower cholesterol (P=.001), high-density lipoprotein (P=.006), and low-density lipoprotein (P=.008) levels were more likely to be observed among patients with high ALT levels. In a multivariate analysis, younger age (OR 0.96, 95% CI 0.93-0.99), being male (OR 0.23, 95% CI 0.09-0.57), and a lower cholesterol level (OR 0.55, 95% CI 0.37-0.82) were significant predictors of high ALT levels. CONCLUSION: Based on the high prevalence of obesity and diabetes, the prevalence of NAFLD will continue to be high, unless awareness is inculcated among the local population. |
| Databáze: | OpenAIRE |
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