Taurolidine peritoneal lavage as prophylaxis against infection after elective colorectal surgery
| Autor: | J. A. Jones, David L. Morris, J. H. Lloyd, D Baker, Jack D. Hardcastle, Jonathan S. Nguyen-Van-Tam, J. B. Bourke, Robert Steele |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Colon Taurine medicine.medical_treatment Antibiotics Rectum chemistry.chemical_compound Peritoneum medicine Humans Surgical Wound Infection Peritoneal Lavage Saline Chemotherapy Intraoperative Care Thiadiazines business.industry Incidence (epidemiology) Taurolidine Middle Aged Colorectal surgery Surgery medicine.anatomical_structure chemistry Elective Surgical Procedures Anti-Infective Agents Local Female business |
| Zdroj: | The British journal of surgery. 81(7) |
| ISSN: | 0007-1323 |
| Popis: | A total of 300 patients undergoing elective colorectal surgery over a 3-year period were randomly assigned to receive intraoperative peritoneal lavage with either taurolidine or saline. Culture swabs were taken from the region of surgery before and after lavage and the development of postoperative infection monitored. Of the positive culture swabs before lavage, a significantly higher proportion were negative after lavage with taurolidine than after that with saline. However, there was no difference in the incidence of postoperative infection between groups, suggesting that taurolidine intraoperative peritoneal lavage confers no clinical benefit over that with saline. |
| Databáze: | OpenAIRE |
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