Adaptive response of resistant cancer cells to chemotherapy
| Autor: | Yi-Jye Chern, Isabella T. Tai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Senescence Cancer Research Aging autophagy senescence medicine.medical_treatment Context (language use) Antineoplastic Agents Apoptosis Review chemotherapy lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Neoplasms adaptive response Medicine Animals Humans Cancer Chemotherapy business.industry ER stress signaling Autophagy chemoresistance Adaptive response lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Endoplasmic Reticulum Stress Adaptation Physiological 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Cancer research Personalized medicine business |
| Zdroj: | Cancer Biology & Medicine Cancer Biology & Medicine, Vol 17, Iss 4, Pp 842-863 (2020) |
| ISSN: | 2095-3941 |
| Popis: | Despite advances in cancer therapeutics and the integration of personalized medicine, the development of chemoresistance in many patients remains a significant contributing factor to cancer mortality. Upon treatment with chemotherapeutics, the disruption of homeostasis in cancer cells triggers the adaptive response which has emerged as a key resistance mechanism. In this review, we summarize the mechanistic studies investigating the three major components of the adaptive response, autophagy, endoplasmic reticulum (ER) stress signaling, and senescence, in response to cancer chemotherapy. We will discuss the development of potential cancer therapeutic strategies in the context of these adaptive resistance mechanisms, with the goal of stimulating research that may facilitate the development of effective cancer therapy. |
| Databáze: | OpenAIRE |
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