Factors Influencing the Distribution of Metastases and Survival in Metastatic Breast Carcinoma
| Autor: | Ibrahim Barista, Şevket Ruacan, Esmen Baltali, Ayse Kars, Nilüfer Güler, Ibrahim Gullu, Gülten Tekuzman, Yavuz Ozisik, Ismail Celik, Ibtisam Lale Atahan, Dincer Firat, Saraçbaşi O |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Pathology Turkey Mammary gland Estrogen receptor Bone Neoplasms Breast Neoplasms Soft Tissue Neoplasms Metastasis Mastectomy Modified Radical Risk Factors Internal medicine Carcinoma Humans Medicine Aged Neoplasm Staging Retrospective Studies Aged 80 and over Analysis of Variance Univariate analysis business.industry Mortality rate Carcinoma Ductal Breast Age Factors Soft tissue Middle Aged Ductal carcinoma Prognosis medicine.disease Survival Rate Viscera Treatment Outcome medicine.anatomical_structure Receptors Estrogen Lymphatic Metastasis Multivariate Analysis Female Menopause Mastectomy Radical business |
| Zdroj: | American Journal of Clinical Oncology. 19:569-573 |
| ISSN: | 0277-3732 |
| Popis: | A total of 370 patients with metastatic breast, carcinoma who had been followed at Hacettepe Oncology Department between 1980 and 1991 were retrospectively analyzed for the factors influencing the distribution of metastases and survival. Median age was 47 years. Radical or modified radical mastectomies were performed in 199 (53.8%). Infiltrative ductal carcinoma was the most common pathologic subtype (69.4%). In 191 patients who were evaluated for estrogen receptor (ER) status, 101 (52.9%) were positive and 90 (47.1%) were negative. The distribution of first metastases did not differ between the soft tissue, bone, and visceral sites. The second, third, and fourth metastases were more common in visceral sites (p < 0.05). ER and menopausal status did not affect distribution. Mortality rate was significantly lower in the group having the first metastasis to the bone (p < 0.05). Of interest, first metastases were predominantly found in visceral sites in patients having radical or modified radical mastectomies (p < 0.05). Response to therapy, presence of initial metastases, axillary status, and age were the important factors influencing the overall survival in univariate analysis, whereas response to therapy, ER status, age, and presence of initial metastases were the important factors according to the multivariate analysis. |
| Databáze: | OpenAIRE |
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