Iron deficiency and malaria among children living on the coast of Kenya
| Autor: | Thomas N. Williams, Alex K. Chemtai, Alice M Nyakeriga, Jeffrey R. Dorfman, Moses Kortok, Rune Bäck, Marita Troye-Blomberg, Kevin Marsh, Neal Alexander |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Anemia
Iron Population Plasmodium falciparum Physiology Nutritional Status Antibody Specificity parasitic diseases Immunology and Allergy Medicine Animals Humans Malaria Falciparum education Child education.field_of_study biology Anemia Iron-Deficiency business.industry Incidence (epidemiology) Incidence Infant Iron deficiency Immunoglobulin E biology.organism_classification medicine.disease Kenya Ferritin Infectious Diseases Cross-Sectional Studies Iron-deficiency anemia Child Preschool Immunoglobulin G Immunology Ferritins biology.protein business Malaria |
| Popis: | Both iron deficiency and malaria are common in much of sub-Saharan Africa, and the interaction between these conditions is complex. To investigate the association between nutritional iron status, immunoglobulins, and clinical Plasmodium falciparum malaria, we determined the incidence of malaria in a cohort of children between the ages of 8 months and 8 years who were living on the Kenyan coast. Biochemical iron status and malaria-specific immune responses were determined during 2 cross-sectional surveys. We found that the incidence of clinical malaria was significantly lower among iron-deficient children (incidence-rate ratio [IRR], 0.70; 95% confidence interval [CI], 0.51-0.99; P |
| Databáze: | OpenAIRE |
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