The distribution of T lymphocytes, B lymphocytes, and dendritic-like cells of the anal tonsil in the laboratory shrew, Suncus murinus
| Autor: | Genzoh Isomura, Hideki Imada, Masanori Shinzato, Kazuyoshi Sakai, Keiki Yamada |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Pathology
medicine.medical_specialty Histology T-Lymphocytes Palatine Tonsil Anal Canal stomatognathic system Antigen biology.animal Animals Laboratory medicine Distribution (pharmacology) Animals Intestinal Mucosa Instrumentation B-Lymphocytes biology Follicular dendritic cells Shrews Shrew Suncus Dendritic Cells biology.organism_classification Medical Laboratory Technology medicine.anatomical_structure Lymphatic system Tonsil Protective antibody Anatomy |
| Zdroj: | Microscopy research and technique. 74(9) |
| ISSN: | 1097-0029 |
| Popis: | We investigated the distribution of T lymphocytes, B lymphocytes, and S-100 protein-immunoreactive dendritic-like in the anal tonsil of the laboratory shrew, Suncus murinus. In adult animals, T lymphocytes were located mainly at the periphery of the anal tonsil, especially around small blood vessels. B lymphocytes were located in the central and subepithelial region of the anal tonsil, which includes primary lymphoid follicles, and in which there are small numbers of scattered T lymphocytes. B and T lymphocytes were distributed over 72.7 and 27.3% of the tonsillar area, respectively. However, their areas of distribution were not clearly distinguished. The areas containing B lymphocytes were enriched in S-100 protein antibody-immunoreactive cells, which exhibited a dendritic shape. These S-100-positive cells appeared to be identical to the follicular dendritic cells (FDC) seen in the follicles of lymphoid organs. These results suggest that the anal tonsils constitute one of the gut-associated lymphoid tissues (GALT), and that a function of the anal tonsil includes the capture of intruding antigens that would generate protective antibody responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text