ANTI-INFLAMMATORY EFFECTS OF THEOPHYLLINE: MODULATION OF IMMUNE FUNCTIONS DURING MURINE LEUKEMIA VIRUS INFECTION
| Autor: | Zhen Zhang, Bailin Liang, David Solkoff, Paula Inserra, Jeongmin Lee, Shuguang Jiang, Ronald R. Watson |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
T-Lymphocytes
medicine.medical_treatment T cell Immunology Apoptosis Lymphocyte Activation Toxicology Virus Mice Immune system Theophylline Murine leukemia virus medicine Animals Immunology and Allergy Pharmacology B-Lymphocytes Leukemia Experimental biology Anti-Inflammatory Agents Non-Steroidal General Medicine biology.organism_classification medicine.disease Leukemia Virus Murine Mice Inbred C57BL Tumor Virus Infections Leukemia Cytokine medicine.anatomical_structure B-cell leukemia Cytokines Female Spleen Retroviridae Infections medicine.drug |
| Zdroj: | Immunopharmacology and Immunotoxicology. 23:307-319 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.1081/iph-100107332 |
| Popis: | LP-BM5 murine leukemia virus induces immune dysfunction leading to B cell leukemia and murine AIDS with cytokine dsyregulation. Theophylline induces apoptosis of leukemia cells in humans. Therefore the effects of theophylline on immune dysfunction in a murine model of leukemia were investigated. C57BL/6 mice consumed drinking water containing 0.3% theophylline beginning 2 weeks after murine retrovirus infection for 4 months. Theophylline largely prevented the retrovirus induced splenomagaly, lymphodenopathy, reduction in B and T cell proliferation, and suppression of Thl cytokines (IL-2) secretion. It also suppressed Th2 cytokine (IL-4, TNF-alpha, and IL-10) production, which was otherwise stimulated by retrovirus infection. These data suggest that immune dysfunction, induced by murine retrovirus infection, was largely prevented by theophylline treatment. |
| Databáze: | OpenAIRE |
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