Use of intravenous immune globulin in addition to antiviral therapy in the treatment of CMV gastrointestinal disease in allogeneic bone marrow transplant patients: a report from the European Group for Blood and Marrow Transplantation (EBMT)
Autor: | Catherine Cordonnier, AJ Robinson, Adrian C. Newland, M Rovira, H. Einsele, H. G. Prentice, J. Gmür, R de la Cámara, Per Ljungman, W Rösler, D Veil, C Bender-Götze, Alberto Bosi, A. W. Dekker |
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Rok vydání: | 1998 |
Předmět: |
Adult
Male Human cytomegalovirus medicine.medical_specialty Adolescent Gastrointestinal Diseases medicine.medical_treatment Pneumonia Viral Antiviral Agents Betaherpesvirinae Surveys and Questionnaires Internal medicine medicine Humans Transplantation Homologous Child Bone Marrow Transplantation Retrospective Studies Transplantation Chemotherapy biology Proportional hazards model business.industry Immunoglobulins Intravenous Hematology Immunotherapy Middle Aged biology.organism_classification medicine.disease Treatment Outcome medicine.anatomical_structure Gastrointestinal disease Cytomegalovirus Infections Immunology Female Viral disease Bone marrow business |
Zdroj: | Bone Marrow Transplantation. 21:473-476 |
ISSN: | 1476-5365 0268-3369 |
Popis: | The best treatment of CMV gastrointestinal disease has been controversial, with some centers adding intravenous (i.v.) Ig to antiviral chemotherapy. The aim of this retrospective survey was to compare the outcome of antiviral chemotherapy with or without i.v. Ig. A questionnaire was sent to centers belonging to the EBMT. Thirty-three patients with CMV gastrointestinal disease were reported, 22 patients were given antiviral chemotherapy alone and 11 patients a combination of antiviral chemotherapy and i.v. Ig. Eighteen of 33 (55%) patients responded to therapy, 13 of those treated with antiviral chemotherapy alone and five (45%) of those treated with the combination (P = NS). Patients with acute GVHD of grades II-IV had significantly worse outcomes than patients with acute GVHD grades 0-I. In a Cox proportional hazards model corrected for acute GVHD there was no difference in outcome of CMV gastrointestinal disease with or without addition of Ig. Survival at 100 days after diagnosis of CMV gastrointestinal disease was 64%. There was no difference in survival in patients treated with or without i.v. Ig. The results of this retrospective survey indicate that addition of i.v. Ig to antiviral chemotherapy might not improve outcome in patients with biopsy-proven CMV gastrointestinal disease. |
Databáze: | OpenAIRE |
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