Differential utilization of two ATP-generating pathways is regulated by p53
| Autor: | Wissam Assaily, Samuel Benchimol |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Cancer Research
Multiprotein complex Cellular respiration Citric Acid Cycle Oxidative phosphorylation Oxidative Phosphorylation Electron Transport Complex IV 03 medical and health sciences Mice 0302 clinical medicine Adenosine Triphosphate Neoplasms medicine Cytochrome c oxidase Animals Glycolysis 030304 developmental biology 0303 health sciences biology L-Lactate Dehydrogenase Mechanism (biology) Cancer Cell Biology medicine.disease Cell biology Mitochondria Isoenzymes Oncology Biochemistry 030220 oncology & carcinogenesis Cancer cell biology.protein Lactate Dehydrogenase 5 Tumor Suppressor Protein p53 Energy Metabolism Molecular Chaperones |
| Zdroj: | Cancer Cell. (1):4-6 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccr.2006.06.014 |
| Popis: | A fundamental property of cancer cells is the preferential utilization of glycolysis over aerobic respiration to produce ATP. Renewed interest in understanding the mechanism underlying this metabolic shift in energy production is broadening our understanding of the relationship between cancer and cellular metabolism. In a recent article, Matoba et al. report that the p53 tumor suppressor regulates the expression of SCO2, a protein that is required for the assembly of cytochrome c oxidase (COX), a multimeric protein complex required for oxidative phosphorylation. The implication of these findings is that aerobic respiration is compromised in cells that lack functional p53. |
| Databáze: | OpenAIRE |
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