Effects of Coronary Prestenting Platelet Inhibition on Coronary Poststenting Inflammation
| Autor: | Carlos Macaya, Antonio López-Farré, Daniel Sacristán, Luis Azcona, Jerónimo Farré, José J. Zamorano-León, Antonio Fernández-Ortiz, Jose R. Romero |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Ticlopidine Time Factors Platelet Aggregation Inflammatory response Myocardial Infarction Inflammation Platelet Glycoprotein GPIIb-IIIa Complex Platelet inhibition Gastroenterology Drug Administration Schedule Internal medicine Humans Medicine Platelet cardiovascular diseases Platelet activation Myocardial infarction Infusions Intravenous Aged Pharmacology business.industry medicine.disease Clopidogrel Tirofiban alpha 1-Antitrypsin Immunology Tyrosine Female Stents medicine.symptom Cardiology and Cardiovascular Medicine business Glycoprotein IIb/IIIa Platelet Aggregation Inhibitors |
| Zdroj: | ResearcherID |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/fjc.0b013e318163a90f |
| Popis: | The aim of this study was to analyze the effect of 2 antiplatelet regimens on the inhibition of GP IIb/IIIa-dependent platelet activation and their association with the poststenting inflammatory response. Seventeen patients with acute myocardial infarction were divided into 2 groups: (A) clopidogrel plus tirofiban infusion administered together during inclusion (n = 10); (B) clopidogrel administered at inclusion and followed 2 hours after by tirofiban (n = 7). Blood samples were obtained at inclusion and at 24 and 48 hours after stenting. Before stenting, a greater reduction of GP IIb/IIIa-dependent platelet activation was found in both groups, although it was greater in group A than in group B. This statistical difference was not observed at 24 and 48 hours after the procedure. At 48 hours after stenting, interleukin-6, interleukin-10, soluble intracellular adhesion molecule-1, and soluble CD40 ligand plasma values were not different between experimental groups. By proteomics, different isoforms of the following proteins were identified: alpha 1-antitrypsin (ATT-1), fibrinogen gamma chain, apolipoprotein A-IV, apolipoprotein A-I, vitamin D binding protein, haptoglobin, and serotransferrin. At 48 hours after stenting, only the plasma expression of the ATT-1 isoform 5 was significantly increased in group A compared with group B. In conclusion, a greater inhibition of GP IIb/IIIa-dependent platelet activation before stenting was not correlated with a different inflammatory activity early after stenting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|