New adjuvants to enhance anticoagulant activity of warfarin
| Autor: | Jeremiah J. Stromich, David E. Lewis, Ashley K. Weber, Yousef R. Mirzaei, Michael D. Caldwell |
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| Rok vydání: | 2009 |
| Předmět: |
Agonist
Male Anticoagulant effect medicine.drug_class Clinical Biochemistry Pharmaceutical Science Anti coagulation Pharmacology Biochemistry Anticoagulant activity Rats Sprague-Dawley Drug Discovery medicine Animals heterocyclic compounds cardiovascular diseases Molecular Biology Chemistry Organic Chemistry Antagonist Warfarin Anticoagulants Drug Synergism Rats Oral anticoagulant Molecular Medicine VKORC1 medicine.drug |
| Zdroj: | Bioorganicmedicinal chemistry letters. 20(6) |
| ISSN: | 1464-3405 |
| Popis: | New adjuvants of warfarin anticoagulant activity have been developed. These compounds, which are 1,4-methano-1,2,3,4-tetrahydroanthracene-9,10-diol derivatives, act synergistically with warfarin to potentiate its anticoagulant effect. None of the compounds tested is an effective oral anticoagulant in the absence of warfarin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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