ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer
| Autor: | Alexander Bachmann, Martin Braun, Karen Petersen, Falko Fend, Sven Perner, Gregor Scharf, Nicolas Wernert, Glen Kristiansen, Veit Scheble, Tobias Zellweger, Zaki Shaikhibrahim, Susanna Stürm, Christian Ruiz, Rudi Beschorner, Lukas Bubendorf |
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| Rok vydání: | 2012 |
| Předmět: |
Male
PCA3 Oncology medicine.medical_specialty Antineoplastic Agents Hormonal TMPRSS2 Pathology and Forensic Medicine Prostate cancer Transcriptional Regulator ERG Internal medicine medicine Humans Castration Neoplasm Metastasis Molecular Biology In Situ Hybridization Fluorescence Gene Rearrangement business.industry Gene Amplification Prostatic Neoplasms Cancer Cell Biology General Medicine Gene rearrangement medicine.disease Androgen receptor Drug Resistance Neoplasm Receptors Androgen Tissue Array Analysis Trans-Activators Neoplasm Recurrence Local business Erg |
| Zdroj: | Virchows Archiv. 461:157-162 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-012-1270-7 |
| Popis: | Castration-resistant prostate cancer is the second most common cause of cancer death and results in a median survival of less than 2 years. In prostate cancer, fusions between TMPRSS2 and ERG are common. The ERG rearrangement prevalence in local recurrent castration-resistant prostate cancer compared to distant metastatic prostate cancer is unknown. We investigated the frequency of ERG rearrangement in local recurrent castration-resistant prostate cancer compared to distant metastatic prostate cancer, and assessed for associations between androgen receptor (AR) amplification and ERG rearrangement status. Samples from 134 patients diagnosed with prostate cancer (84 local recurrent castration resistant prostate cancer, 55 distant metastatic prostate cancer) were assessed for their ERG rearrangement and AR amplification status by fluorescence in situ hybridization. Statistical analysis was performed using the χ (2) test. We found that the ERG rearrangement occurs at a significantly lower frequency in distant metastatic prostate cancer (25 %) than in local recurrent castration-resistant prostate cancer (45 %). The AR amplification frequencies were 45 and 35 % in local recurrent castration-resistant prostate cancer and distant metastatic prostate cancer, respectively. The ERG rearrangement occurred at a lower frequency in distant metastatic prostate cancer compared to local recurrent castration-resistant prostate cancer. |
| Databáze: | OpenAIRE |
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