Conformal radiotherapy, reduced boost volume, hyperfractionated radiotherapy, and online quality control in standard-risk medulloblastoma without chemotherapy: results of the French M-SFOP 98 protocol
| Autor: | Valérie Bernier, Bernard Vie, Frederic Lafay, Xavier Muracciole, Jean-Louis Habrand, Marc Mahe, Zineb Gaci, M Benhassel, Sophie Chapet, Sylvette Hoffstetter, Claire Alapetite, Frederic Gomez, Marie Helene Baron, Christian Carrie, Philippe Quetin, Pierre Clavere, Françoise Soum, H. Kolodie, Martine Mege, Jean Philippe Maire, Philippe Maingon, Jacques Grill |
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| Rok vydání: | 2004 |
| Předmět: |
Quality Control
Cancer Research Adolescent medicine.medical_treatment Pilot Projects Cognition medicine Humans Radiology Nuclear Medicine and imaging Cerebellar Neoplasms Child Survival rate Survival analysis Medulloblastoma Chemotherapy Radiation business.industry Dose fractionation medicine.disease Survival Analysis Hyperfractionated radiotherapy Radiation therapy Treatment Outcome Oncology Feasibility Studies Dose Fractionation Radiation France Neoplasm Recurrence Local Radiotherapy Conformal Nuclear medicine business Volume (compression) |
| Zdroj: | International journal of radiation oncology, biology, physics. 63(3) |
| ISSN: | 0360-3016 |
| Popis: | Between December 1998 and October 2001, patients19 years old were treated for standard-risk medulloblastoma according to the Medulloblastome-Société Française d'Oncologie Pédiatrique 1998 (M-SFOP 98) protocol. Patients received hyperfractionated radiotherapy (36 Gy in 36 fractions) to the craniospinal axis, a boost with conformal therapy restricted to the tumor bed (to a total dose of 68 Gy in 68 fractions), and no chemotherapy. Records of craniospinal irradiation were reviewed before treatment start.A total of 48 patients were considered assessable. With a median follow-up of 45.7 months, the overall survival and progression-free survival rate at 3 years was 89% and 81%, respectively. Fourteen major deviations were detected and eight were corrected. No relapses occurred in the frontal region and none occurred in the posterior fossa outside the boost volume. Nine patients were available for volume calculation without reduction of the volume irradiated. We observed a reduction in the subtentorial volume irradiated to60 Gy, but a slight increase in the volume irradiated to 40 Gy. No decrease in intelligence was observed in the 22 children tested during the first 2 years.This hyperfractionated radiotherapy protocol with a reduced boost volume and without chemotherapy was not associated with early relapses in children. Moreover, intellectual function seemed to be preserved. These results are promising. |
| Databáze: | OpenAIRE |
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