Development of Prodrugs for PDT-Based Combination Therapy Using a Singlet-Oxygen-Sensitive Linker and Quantitative Systems Pharmacology
| Autor: | Sukyung Woo, Youngjae You, Luong T. Nguyen, Mengjie Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Physiologically based pharmacokinetic modelling
Combination therapy medicine.medical_treatment Photodynamic therapy Review Pharmacology 010402 general chemistry 01 natural sciences SN-38 light-activatable prodrugs combination therapy chemistry.chemical_compound paclitaxel Pharmacokinetics PDT Medicine 010405 organic chemistry business.industry General Medicine aminoacrylate Prodrug 3. Good health 0104 chemical sciences Paclitaxel chemistry photodynamic therapy physiologically based pharmacokinetic modeling quantitative systems pharmacology business Linker singlet-oxygen-sensitive linker pharmacokinetics Combretastatin A-4 Systems pharmacology |
| Zdroj: | Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Popis: | Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in which anticancer drugs are activated locally at tumor sites during PDT treatment. The development of a singlet-oxygen-sensitive linker that can be conveniently conjugated to various drugs and efficiently cleaved to release intact drugs is recapitulated. The initial design of prodrugs, preliminary efficacy evaluation, pharmacokinetics study, and optimization using quantitative systems pharmacology is discussed. Current treatment optimization in animal models using physiologically based a pharmacokinetic (PBPK) modeling approach is also explored. |
| Databáze: | OpenAIRE |
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