Systematic Review and Bayesian Meta-analysis of the Dose-response Relationship between Folic Acid Intake and Changes in Blood Folate Concentrations
Autor: | Ahlia Sekkarie, Yan Ping Qi, Owen Devine, Eugene Wong, Charles E. Rose, Lorraine F Yeung, Krista S. Crider, Ibrahim Zaganjor, Robert J. Berry |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Dose fortification Nutritional Status Physiology lcsh:TX341-641 Review 03 medical and health sciences folic acid 0302 clinical medicine Pharmacokinetics Humans Medicine 030212 general & internal medicine red blood cell folate 030109 nutrition & dietetics Nutrition and Dietetics Dose-Response Relationship Drug business.industry Blood folate Food fortification plasma folate public health Bayes Theorem Dose–response relationship Red blood cell medicine.anatomical_structure Meta-analysis Food Fortified supplementation serum folate business lcsh:Nutrition. Foods and food supply Homeostasis Food Science |
Zdroj: | Nutrients, Vol 11, Iss 1, p 71 (2019) Nutrients |
ISSN: | 2072-6643 |
Popis: | The threshold for population-level optimal red blood cell (RBC) folate concentration among women of reproductive age for the prevention of neural tube defects has been estimated at 906 nmol/L; however, the dose-response relationship between folic acid intake and blood folate concentrations is uncharacterized. To estimate the magnitude of blood folate concentration increase in response to specific dosages of folic acid under steady-state conditions (as could be achieved with food fortification), a systematic review of the literature and meta-analysis was conducted. Of the 14,002 records we identified, 533 were selected for full-text review, and data were extracted from 108 articles. The steady-state concentrations (homeostasis) of both serum/plasma and RBC folate concentrations were estimated using a Bayesian meta-analytic approach and one-compartment physiologically-based pharmacokinetic models. RBC folate concentrations increased 1.78 fold (95% credible interval (CI): 1.66, 1.93) from baseline to steady-state at 375–570 µg folic acid/day, and it took a median of 36 weeks of folic acid intake (95% CI: 27, 52) to achieve steady-state RBC folate concentrations. Based on regression analysis, we estimate that serum/plasma folate concentrations increased 11.6% (95% CI: 8.4, 14.9) for every 100 µg/day folic acid intake. These results will help programs plan and monitor folic acid fortification programs. |
Databáze: | OpenAIRE |
Externí odkaz: |