Decreased expression of cytochrome P-452 in the resistance phenotype characteristic of putative preneoplastic hepatocyte nodules during hepatocarcinogenesis
| Autor: | Emmanuel Farber, M.A. Bacher, D.V. Parke, M.W. Roomi, G.G. Gibson |
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| Rok vydání: | 1988 |
| Předmět: |
Male
Cytochrome Drug Resistance Biophysics Biology Biochemistry Isozyme Mixed Function Oxygenases Hydroxylation chemistry.chemical_compound Liver Neoplasms Experimental Cytochrome P-450 Enzyme System Cytochrome P-450 CYP1A1 medicine Animals Molecular Biology Heme Cell Biology Phenotype Rats Inbred F344 Rats medicine.anatomical_structure Liver chemistry Hepatocyte Microsome biology.protein Cytochromes Phenobarbital Cytochrome P-450 CYP4A Oxidoreductases Precancerous Conditions Aminopyrine N-Demethylase medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 152:921-925 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/s0006-291x(88)80128-1 |
| Popis: | Hepatocyte nodules, a characteristic early step in the development of liver cancer in rats, has a distinctive resistance phenotype including a large decrease in total cytochromes P-450 and in two isozymes induced by phenobarbital and two by 3-methylcholanthrene. In this study, it has been observed that the nodules show a large decrease in an additional cytochrome P-450, cytochrome P-452, which is very active in the hydroxylation of lauric acid at C-11 and C-12. The decrease in activity of this microsomal cytochrome P-452 is of the same order of magnitude as the decreases in the other cytochrome P-450 components. These observations are consistent with the hypothesis that there is some more basic alteration in the synthesis or availability of heme and that the changes in the activities of the cytochromes P-450 are secondary. |
| Databáze: | OpenAIRE |
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