Multi-Omics Characterization and Origin Assessment of Bilateral Lung Adenoid Cystic Carcinoma: A Case Report
| Autor: | Xiaoshun Shi, Jianfei Shen, Sijia Ren, Minhua Ye, Chunguo Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Adenoid cystic carcinoma Case Report 03 medical and health sciences 0302 clinical medicine medicine adenoid cystic carcinoma Liquid biopsy Lung business.industry Genetic Alteration PIK3R1 medicine.disease Omics Lung Adenoid Cystic Carcinoma 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Multi omics next-generation sequencing Radiology lung cancers of unknown primary site Differential diagnosis business |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| DOI: | 10.2147/cmar.s292789 |
| Popis: | Background Primary adenoid cystic carcinoma (ACC) of the lung, which arises from the bronchial gland and is rare, accounting for only 0.04-0.2% of all primary lung tumors. The genetic profiling of bilateral ACC of unknown primary site and application in postoperative decision-making are less reported. Case presentation A 57-year-old male with a smoking history of over 30 years and multiple nodules in both lungs was present to our department. After assessing the bilateral solid nodules in his Positron Emission Tomography-Computed Tomography (PET/CT) scan, malignant lesions at the left lower lung, right lower lung, and right middle lung are suspected. Sequential selective video-assisted thoracoscopic surgeries (VATS) were performed. A genetic alteration test of 425 cancer-related genes and global gene expression profile of the specimens revealed intrapulmonary metastasis existed. The patient was followed up for three years without recurrence and tissue mutations in liquid biopsy. Conclusion We present a way of omics-based multiple pulmonary lesions origin assessment, facilitating post-operative differential diagnosis and treatment decision for difficult cases. |
| Databáze: | OpenAIRE |
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