| Autor: |
Santosh Wakode, Sandip Hulke, Naina S Wakode, Tanusha Pathak, Ragini Shrivastava, Avinash Thakare, Varun Malhotra |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Cureus. 14(11) |
| ISSN: |
2168-8184 |
| Popis: |
Major depression is a chronic condition that may affect cognition. Cognitive disturbances may affect clinical scales used to assess the severity of depression.To find an association between cognitive disturbance as objectively recorded using event-related potentials (P300) with the Hamilton rating scale for depression (HAM-D) and Montgomery-Asberg depression rating scale (MADRS) in newly diagnosed cases of major depression.A cross-sectional study with a sample size of 46 diagnosed cases of major depression. The assessment was done using the HAM-D and MADRS. The P300 assessment was done with the auditory oddball paradigm using the Nihon Kohden NCV-SMG-EP system (Tokyo, Japan).Pearson correlation analysis was used to study the association between various parameters of P300 and the HAM-D and MADRS depression rating scales.A significant correlation was found between A21- P300 amplitude Cz and the MADRS score. No significant correlation was seen between other P300 parameters and HAM-D and MADRS scales.As the results were objectively recorded using various parameters of event-related potentials (P300), cognitive impairment was not significantly associated with depression rating scales i.e., the HAM-D and MADRS scores. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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