Serum bilirubin value predicts hospital admission in carbon monoxide-poisoned patients. Active player or simple bystander?
| Autor: | Alessandra Picanza, Ruggero Buonocore, Gianfranco Cervellin, Ivan Comelli, Giuseppe Lippi, Gianni Rastelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Bilirubin Endpoint Determination Gastroenterology chemistry.chemical_compound Carbon Monoxide Poisoning Hemoglobins Young Adult Patient Admission poison Predictive Value of Tests Internal medicine Medicine Humans Lactic Acid Retrospective Studies lcsh:R5-920 Univariate analysis Carbon Monoxide business.industry Carbon monoxide poisoning Diagnostic Tests Routine Poisoning Area under the curve Retrospective cohort study bilirubin monoxide poison General Medicine Clinical Science Middle Aged medicine.disease Surgery monoxide chemistry Carboxyhemoglobin Predictive value of tests Area Under Curve Lactate Female Hemoglobin bilirubin lcsh:Medicine (General) business Biomarkers |
| Zdroj: | Clinics, Volume: 70, Issue: 9, Pages: 628-631, Published: SEP 2015 Clinics Clinics; v. 70 n. 9 (2015); 628-631 Clinics; Vol. 70 Núm. 9 (2015); 628-631 Clinics; Vol. 70 No. 9 (2015); 628-631 Universidade de São Paulo (USP) instacron:USP Clinics, Vol 70, Iss 9, Pp 628-631 |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: Although carbon monoxide poisoning is a major medical emergency, the armamentarium of recognized prognostic biomarkers displays unsatisfactory diagnostic performance for predicting cumulative endpoints. METHODS: We performed a retrospective and observational study to identify all patients admitted for carbon monoxide poisoning during a 2-year period. Complete demographical and clinical information, along with the laboratory data regarding arterial carboxyhemoglobin, hemoglobin, blood lactate and total serum bilirubin, was retrieved. RESULTS: The study population consisted of 38 poisoned patients (23 females and 15 males; mean age 39±21 years). Compared with discharged subjects, hospitalized patients displayed significantly higher values for blood lactate and total serum bilirubin, whereas arterial carboxyhemoglobin and hemoglobin did not differ. In a univariate analysis, hospitalization was significantly associated with blood lactate and total serum bilirubin, but not with age, sex, hemoglobin or carboxyhemoglobin. The diagnostic performance obtained after combining the blood lactate and total serum bilirubin results (area under the curve, 0.90; 95% CI, 0.81-0.99; p |
| Databáze: | OpenAIRE |
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