Can zinc be an adjuvant therapy for juvenile onset recurrent respiratory papillomatosis?
| Autor: | Nabil Fuleihan, Musa Muallem, Mohamed A. Bitar, Rami Baz |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Adolescent medicine.medical_treatment Organophosphonates Antiviral Agents Cytosine Pharmacotherapy Internal medicine medicine Adjuvant therapy Humans Laryngeal Neoplasms HspE7 Papilloma business.industry General Medicine medicine.disease Surgery Discontinuation Zinc Regimen Otorhinolaryngology Chemotherapy Adjuvant Child Preschool Pediatrics Perinatology and Child Health Zinc deficiency Drug Therapy Combination Recurrent Respiratory Papillomatosis business Adjuvant Cidofovir |
| Zdroj: | International Journal of Pediatric Otorhinolaryngology. 71:1163-1173 |
| ISSN: | 0165-5876 |
| DOI: | 10.1016/j.ijporl.2007.05.008 |
| Popis: | Summary Objectives To report a severe case of juvenile onset recurrent respiratory papillomatosis (JORRP) controlled by zinc replacement therapy. To review the contemporary adjuvant therapies used in JORRP. Methods The trial of zinc was described in terms of its effect on the inter-surgical interval, site score and clinical symptoms. Long-term follow-up with dose adjustment was detailed. Articles reporting trials of adjuvant therapies over the past 20 years were reviewed in terms of regimen used, mode of assessment, side effects and final outcome. Results Zinc was effective in decreasing the severity of the disease, the rate of relapse and the need for surgery. There was an obvious relation between the dose used and the degree of improvement. Prolonged treatment seems to be needed to sustain the positive effect. No side effects were noticed over a 45-month follow-up period. The literature does support the role of zinc in modulating the immune system. Eight adjuvant therapies were reviewed as published in 40 reports. Interferon was the most used substance. It is definitely effective but often associated with relapse upon discontinuation. The effect of cidofovir was favorable yet not dramatic as initially expected. Other less commonly used therapies showed humble effects. The HspE7 vaccine seems to be promising awaiting further trials. Conclusions Zinc replacement therapy may benefit JORRP patients with zinc deficiency and should be investigated in more cases. Several adjuvant therapies are available for use in JORRP. They are generally beneficial though mostly not curative. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect