Late‐Onset Combined Immune Deficiency: A Subset of Common Variable Immunodeficiency with Severe T Cell Defect
| Autor: | Marion, Malphettes, Laurence, Gérard, Maryvonnick, Carmagnat, Gaël, Mouillot, Nicolas, Vince, David, Boutboul, Alice, Bérezné, Raphaële, Nove-Josserand, Vincent, Lemoing, Laurent, Tetu, Jean-François, Viallard, Bernard, Bonnotte, Michel, Pavic, Julien, Haroche, Claire, Larroche, Jean-Claude, Brouet, Jean-Paul, Fermand, Claire, Rabian, Claire, Fieschi, Eric, Oksenhendler, L, Gérard |
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| Přispěvatelé: | Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut Universitaire d'Hématologie (IUH), Université Paris Diderot - Paris 7 (UPD7), Immunité et Infection, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Cochin [AP-HP], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), HIA Desgenettes, Hôpital Avicenne [AP-HP], DEFI Study Group: C Fieschi, M Malphettes, L Galicier, J P Fermand, B Asli, J F Viallard, A Jaccard, C Hoarau, Y Hoarau, A Bérezné, L Mouthon, M Karmochkine, N Schleinitz, I Durieu, R Nove-Josserand, V Chanet, V Le-Moing, N Just, C Salanoubat, R Jaussaud, F Suarez, O Hermine, P Solal-Celigny, E Hachulla, L Sanhes, M Gardembas, I Pellier, P Tisserant, M Pavic, B Bonnotte, J Haroche, Z Amoura, L Alric, M F Thiercelin, L Tetu, D Adoue, P Bordigoni, T Perpoint, P Sève, P Rohrlich, J L Pasquali, P Soulas, J L Couderc, E Catherinot, P Giraud, A Baruchel, I Deleveau, F Chaix, J Donadieu, F Tron, S Jacquot, C Larroche, A P Blanc, A Masseau, M Hamidou, G Kenny, M Morisset, F Millot, O Fain, R Borie, P Debré, C Schmitt, M Le Garff-Tavernier, B Faideau, H Mkada, G Mouillot, J L Garnier, I Théodorou, A G Marcelin, V Calvez, C Rabian, M Carmagnat, C Fieschi, M Malphettes, N Vince, D Boutboul, A De Gouvello, A Gardeur, L Gérard |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Microbiology (medical) T-Lymphocytes Lymphocyte T cell Opportunistic Infections Hypogammaglobulinemia Young Adult Immune system Agammaglobulinemia Immunopathology Humans Medicine Age of Onset B cell Aged biology business.industry Common variable immunodeficiency Middle Aged medicine.disease Common Variable Immunodeficiency Infectious Diseases medicine.anatomical_structure Immunology biology.protein [SDV.IMM]Life Sciences [q-bio]/Immunology Female Antibody business |
| Zdroj: | Clinical Infectious Diseases Clinical Infectious Diseases, 2009, 49 (9), pp.1329-1338. ⟨10.1086/606059⟩ |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1086/606059 |
| Popis: | BACKGROUND Common variable immunodeficiency (CVID) is a primary immune deficiency defined by defective antibody production. In most series, a small proportion of patients present with opportunistic infections (OIs). METHODS The French DEFI study has enrolled patients with primary hypogammaglobulinemia and allows a detailed clinical and immunologic description of patients with previous OIs and/or at risk for OIs. RESULTS Among 313 patients with CVID, 28 patients (8.9%) presented with late-onset combined immune deficiency (LOCID), defined by the occurrence of an OI and/or a CD4(+) T cell count |
| Databáze: | OpenAIRE |
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