Evaluation of HER-2/neu in Serum and Tissue of Primary and Metastatic Breast Cancer Patients using an Automated Enzyme Immunoassay
| Autor: | A Perasole, Matelda Zancan, Ruggero Dittadi, Massimo Gion |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
0301 basic medicine Cancer Research medicine.medical_specialty Pathology Receptor ErbB-2 Clinical Biochemistry Mammary gland Breast Neoplasms Enzyme-Linked Immunosorbent Assay Gastroenterology Pathology and Forensic Medicine Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Carcinoma Humans Neoplasm Metastasis Stage (cooking) Aged Aged 80 and over Oncogene medicine.diagnostic_test business.industry Middle Aged medicine.disease Metastatic breast cancer 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Immunoassay Female business |
| Zdroj: | The International Journal of Biological Markers. 16:255-261 |
| ISSN: | 1724-6008 |
| Popis: | Serum HER-2/neu concentrations were evaluated in 172 healthy subjects, 176 primary and 55 metastatic breast cancer patients, employing a new automated assay (Bayer Immuno 1™ serum HER-2/neu). Using 13 ng/mL as the cutoff, abnormal HER-2/neu serum levels were found in 8% (14/176) of primary and 50.9% (28/55) of metastatic breast cancer patients. Both in primary and metastatic breast cancer a significant relationship was found with the stage of the disease when serum HER-2/neu was considered as a categorized variable (p=0.0003 and p=0.02, respectively), but not when it was taken as a continuous variable (p=0.247 and p=0.146, respectively). Moreover, we evaluated the correlation between Immuno 1™ HER-2/neu and Oncogene Research Products ELISA assay in 53 normal subjects, 46 primary and 34 metastatic breast cancer patients. The correlation was relatively good (p |
| Databáze: | OpenAIRE |
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