Chronic effects of dietary vitamin D deficiency without increased calcium supplementation on the progression of experimental polycystic kidney disease
| Autor: | Sheryl Foster, Mayuresh S. Korgaonkar, Kristina G. Schwensen, Gopala K. Rangan, Anthony Peduto, David Harris |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Physiology Kidney Dietary vitamin vitamin D deficiency Phosphates Internal medicine medicine Kidney injury Polycystic kidney disease Vitamin D and neurology Animals KIDNEY ENLARGEMENT Cholecalciferol Polycystic Kidney Diseases business.industry Vitamin D Deficiency medicine.disease Renal enlargement Rats Calcium Dietary Proteinuria Increased calcium Endocrinology Cardiovascular Diseases Rats Inbred Lew Dietary Supplements Disease Progression business |
| Zdroj: | American Journal of Physiology-Renal Physiology. 305:F574-F582 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00411.2012 |
| Popis: | Increasing evidence indicates that vitamin D deficiency exacerbates chronic kidney injury, but its effects on renal enlargement in polycystic kidney disease (PKD) are not known. In this study, male Lewis polycystic kidney disease (LPK) rats received a normal diet (ND; AIN-93G) supplemented with or without cholecalciferol (vitamin D-deficient diet, VDD; both 0.5% calcium), commenced at either postnatal week 3 (until weeks 10–20; study 1) or from week 10 (until week 20; study 2). Levels of 25-hydroxy vitamin D were reduced in groups receiving the VDD (12 ± 1 nmol/l vs. 116 ± 5 in ND; P < 0.001). In study 1, food intake and weight gain increased by ∼25% in LPK rats receiving the VDD ad libitum, and at week 20 this was associated with a mild reduction in the corrected serum calcium (SCa2+, 7.4%) and TKW:BW ratio (8.8%), and exacerbation of proteinuria (87%) and hypertension (19%; all P < 0.05 vs. ND). When LPK rats were pair-fed for weeks 3–10, there was a further reduction in the SCa2+ (25%) and TKW:BW ratio (22%) in the VDD group ( P < 0.05 vs. ND). In study 2, the VDD did not alter food intake and body weight, reduced SCa2+ (7.7%), worsened proteinuria (41.9%), interstitial monocyte accumulation (26.4%), renal dysfunction (21.4%), and cardiac enlargement (13.2%, all P < 0.05), but there was a trend for a reduction in the TKW:BW ratio (13%, P = 0.09). These data suggest that chronic vitamin D deficiency has adverse long-term actions on proteinuria, interstitial inflammation, renal function, and cardiovascular disease in PKD, and these negate its mild inhibitory effect on kidney enlargement. |
| Databáze: | OpenAIRE |
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