Prostaglandin E2 modulation of blood pressure homeostasis: Studies in rodent models
| Autor: | Christina Elizabeth Swan, Richard M. Breyer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Prostaglandin Antagonists
Physiology medicine.medical_treatment Blood Pressure Rodentia Pharmacology Biology Kidney Biochemistry Article Dinoprostone Renin-Angiotensin System Mice chemistry.chemical_compound Cyclic AMP medicine Animals Humans Receptors Prostaglandin E Vasoconstrictor Agents Prostaglandin E2 Receptor Mice Knockout Kidney metabolism Cell Biology Lipid signaling Prostaglandin antagonist medicine.disease Rats Disease Models Animal Blood pressure chemistry Cardiovascular Diseases Pathophysiology of hypertension Hypertension Kidney Failure Chronic Calcium lipids (amino acids peptides and proteins) Signal Transduction medicine.drug Prostaglandin E |
| Zdroj: | Prostaglandins & Other Lipid Mediators. 96:10-13 |
| ISSN: | 1098-8823 |
| Popis: | Hypertension is a well established risk factor for cardiovascular diseases such as stroke and is the leading cause of chronic kidney failure. Although a number of pharmacologic agents are available for the treatment of hypertension including agents that affect the renin-angiotensin-aldosterone system (RAAS), unmet needs in the treatment of hypertension suggest that identification of novel pharmacological targets would be an important healthcare goal. One potential target is prostaglandin E(2) (PGE(2)), a potent lipid mediator with a diverse and sometimes opposing range of biological effects. PGE(2) signals through four subtypes of G-protein coupled receptors designated EP1 through EP4. PGE(2) functions primarily as a vasodepressor; under certain conditions PGE(2) administration mediates vasopressor activity. This review focuses on the current understanding of the roles of PGE(2) receptors in vascular reactivity, hypertension and end-organ damage. |
| Databáze: | OpenAIRE |
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