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The question of whether the coronavirus genome contain as-yetununderstood genetic component.Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents.A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequences of these two viruses, it was found that base pairing in the cloverleaf model of SARS-CoV-2 was more robust than that of SARS-CoV.The results of homology search between a short sequence of the coronavirus tRNA-like base sequence and human genes suggest that the molecule produced by this novel tRNA-like sequence may be involved in the splicing of human messenger RNA.Experimental molecular evidence of the tRNA-like base sequence discovered in this study is urgently needed. |
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