Effect of Duodenal Mucosal Blood Flow on Duodenal Alkaline Secretion in Rats
| Autor: | Takashi Suzuki, Hidemi Goto, S. Hase, Hiroshi Endo, Hiroshi Hoshino, A. Ohara, Eiji Hamajima, Naoki Ohmiya, Yoshihisa Tsukamoto, Tomiyasu Arisawa |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
musculoskeletal diseases Serotonin medicine.medical_specialty Duodenum Alkalies Secretin Intestinal mucosa Internal medicine medicine Animals Intestinal Mucosa Rats Wistar skin and connective tissue diseases Alkaline secretion business.industry Gastroenterology Blood flow Pathophysiology Rats Pyrimidines Endocrinology medicine.anatomical_structure Regional Blood Flow Duodenal Ulcer Dulcerozine business |
| Zdroj: | Digestion. 51:198-202 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000200898 |
| Popis: | To investigate the role of duodenal mucosal blood flow (DMBF) in the regulation of duodenal alkaline secretion (DAS), both parameters were measured before and after the administration of various drugs in rats. The DMBF was determined using an electrolytically generated hydrogen gas clearance technique, and the DAS was measured by the perfusion method. The administration of dulcerozine, a potent duodenal ulcerogenic agent, at a dose of 250 mg/kg and serotonin at a dose of 20 mg/kg, which produces duodenal ulcerations with an acid load, decreased both DMBF and DAS. On the other hand, the administration of secretin at a dose of 10 U/kg increased both parameters. There were parallel changes in DMBF and DAS. It is concluded, therefore, that DAS may be regulated by DMBF and that both parameters may be involved in the defense mechanism of duodenal mucosa. |
| Databáze: | OpenAIRE |
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