N -Acetylcysteine for Preventing Pump-Induced Oxidoinflammatory Response During Cardiopulmonary Bypass
| Autor: | UgĞur Atik, Ali Gül, Kerem Karaca, Ugur Oral, Ali Ünlü, Ismail Cinel, Barlas Aytacoglu, Lülüfer Tamer, Nehir Sucu, Zeliha Özer Koçak, Murat Dikmengil |
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| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Antioxidants Neutrophil Activation law.invention Acetylcysteine Lipid peroxidation chemistry.chemical_compound Randomized controlled trial Surgical oncology law Malondialdehyde Internal medicine medicine Cardiopulmonary bypass Humans Coronary Artery Bypass Interleukin 6 Peroxidase Inflammation Cardiopulmonary Bypass biology Interleukin-6 business.industry Orosomucoid General Medicine Clinical trial Oxidative Stress C-Reactive Protein surgical procedures operative chemistry Myeloperoxidase Anesthesia Cardiology biology.protein Surgery Lipid Peroxidation Inflammation Mediators business Acute-Phase Proteins circulatory and respiratory physiology medicine.drug |
| Zdroj: | Surgery Today. 34:237-242 |
| ISSN: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-003-2699-8 |
| Popis: | To investigate the effect of N-acetylcysteine on preventing pump-induced oxidoinflammatory response during cardiopulmonary bypass (CPB).Forty patients undergoing coronary artery bypass grafting (CABG) were randomly divided into a study group (n = 20), given 50 mg kg(-1) N-acetylcysteine intravenously for 3 days, and a control group (n = 20) given saline. Serum samples were collected for measurement of myeloperoxidase (MPO), malondialdehyde (MDA), interleukin-6, Alpha1-acid glycoprotein (AAGP), and C-reactive protein (CRP) during surgery and postoperatively.The MPO and MDA values showed a similar pattern during and after CPB in the study group, with significantly less variance than in the control group. Interleukin-6 showed similar patterns in the two groups, but the data from 30 min after the start of CPB and from 6 h post-CPB were significantly different. The AAGP and CRP values were both elevated during CPB in the two groups without a significant difference, but 6 and 24 h post-CPB, the values were significantly higher in the control group than in the study group.N-Acetylcysteine decreased pump-induced oxidoinflammatory response during CPB, suggesting that it could be a novel therapy for assisting in the prevention of CBP-induced oxidoinflammatory damage. |
| Databáze: | OpenAIRE |
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