Survival and morbidity outcomes after pelvic exenteration for pelvic sarcoma: an institutional series
| Autor: | David J Coker, Prashanth Sasidharan, Michael J. Solomon, Peter J Lee, Assad Zahid, Babak Meshkat |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Referral medicine.medical_treatment Locally advanced Pelvic sarcoma Statistical significance medicine Humans Pelvis Pelvic Neoplasms Retrospective Studies Pelvic exenteration Rectal Neoplasms business.industry Sarcoma General Medicine medicine.disease Pelvic Exenteration Surgery Treatment Outcome medicine.anatomical_structure Cohort Morbidity Neoplasm Recurrence Local business |
| Zdroj: | ANZ Journal of Surgery. 92:1038-1043 |
| ISSN: | 1445-2197 1445-1433 |
| DOI: | 10.1111/ans.17275 |
| Popis: | Background To describe our institutional experience in the management of locally advanced primary, and recurrent pelvic sarcoma through pelvic exenteration (PE). Methods Patients undergoing PE for locally advanced primary or recurrent pelvic sarcoma between 2003 and 2017 were identified from a prospectively maintained database at a single quaternary referral hospital in Sydney, Australia were eligible for review. The primary outcomes measured were surgical resection margin and survival. Secondary outcome measures included 30-day morbidity, in hospital length of stay (LOS) and return to theatre. Results There were 29 patients who underwent PE for pelvic sarcoma during the study period, with 55% (n = 16) having advanced primary tumours and 45% (n = 13) having recurrent disease. The R0 resection rate was 52% (n = 15); and five-year-survival of 38% (n = 11). The R0 resection was noted to be higher in patients having primary advanced tumours (56%) compared to those with recurrent disease (46%), however this failed to reach statistical significance in this cohort. There was no recorded 30-day mortality. Grade 3 or higher Clavien-Dindo complications were uncommon (14%), but more likely in patients undergoing surgery for recurrent disease (75%). Conclusion In our cohort of patients with locally advanced and recurrent disease, more than 50% achieved an R0 resection. Recurrent disease makes R0 resection more difficult and can lead to higher morbidity, need for 30-day re-intervention and longer in hospital LOS. PE surgery remains the only curative option for locally advanced, and recurrent sarcoma in the pelvis, and can be performed with acceptable survival and morbidity outcomes. |
| Databáze: | OpenAIRE |
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