Multi-Stage Particle Separation based on Microstructure Filtration and Dielectrophoresis
| Autor: | Jun Yang, Danfen Yin, Xiaoling Zhang, Ning Hu, Xianwei Han |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
lcsh:Mechanical engineering and machinery Microfluidics Dielectrophoresis 02 engineering and technology Microfilter 01 natural sciences Article law.invention chemistry.chemical_compound law lcsh:TJ1-1570 Electrical and Electronic Engineering Composite material Filtration Mechanical Engineering 010401 analytical chemistry 021001 nanoscience & nanotechnology Microstructure Particle separation micropillar 0104 chemical sciences chemistry Control and Systems Engineering Drag Polystyrene 0210 nano-technology Electric field gradient Voltage |
| Zdroj: | Micromachines, Vol 10, Iss 2, p 103 (2019) Micromachines Volume 10 Issue 2 |
| Popis: | Particle separation is important in chemical and biomedical analysis. Among all particle separation approaches, microstructure filtration which based particles size difference has turned into one of the most commonly methods. By controlling the movement of particles, dielectrophoresis has also been widely adopted in particle separation. This work presents a microfluidic device which combines the advantages of microfilters and dielectrophoresis to separate micro-particles and cells. A three-dimensional (3D) model was developed to calculate the distributions of the electric field gradient at the two filter stages. Polystyrene particles with three different sizes were separated by micropillar array structure by applying a 35-Vpp AC voltage at 10 KHz. The blocked particles were pushed off the filters under the negative dielectrophoretic force and drag force. A mixture of Haematococcus pluvialis cells and Bracteacoccus engadinensis cells with different sizes were also successfully separated by this device, which proved that the device can separate both biological samples and polystyrene particles. |
| Databáze: | OpenAIRE |
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