The phospholipid code: a key component of dying cell recognition, tumor progression and host–microbe interactions
| Autor: | Mark D. Hulett, I Kh Poon, Amy A. Baxter |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Extracellular proteins
Cell Phospholipid Review Biology medicine.disease_cause chemistry.chemical_compound Neoplasms Organelle Tumor Microenvironment medicine Humans Molecular Biology Phospholipids Cell Membrane Cell Biology Cell biology medicine.anatomical_structure Biochemistry chemistry Tumor progression Host-Pathogen Interactions Disease Progression lipids (amino acids peptides and proteins) Reactive Oxygen Species Carcinogenesis Intracellular Signal Transduction |
| Zdroj: | Cell Death & Differentiation. 22:1893-1905 |
| ISSN: | 1476-5403 1350-9047 |
| DOI: | 10.1038/cdd.2015.122 |
| Popis: | A significant effort is made by the cell to maintain certain phospholipids at specific sites. It is well described that proteins involved in intracellular signaling can be targeted to the plasma membrane and organelles through phospholipid-binding domains. Thus, the accumulation of a specific combination of phospholipids, denoted here as the ‘phospholipid code', is key in initiating cellular processes. Interestingly, a variety of extracellular proteins and pathogen-derived proteins can also recognize or modify phospholipids to facilitate the recognition of dying cells, tumorigenesis and host–microbe interactions. In this article, we discuss the importance of the phospholipid code in a range of physiological and pathological processes. |
| Databáze: | OpenAIRE |
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