Prolonged targeted temperature management compromises thrombin generation:A randomised clinical trial
| Autor: | Anders Morten Grejs, Susanne Ilkjær, Anne-Mette Hvas, Christophe Henri Valdemar Duez, Anni Nørgaard Jeppesen, Hans Kirkegaard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Time Factors medicine.medical_treatment 030204 cardiovascular system & hematology Emergency Nursing Targeted temperature management Thrombin generation Peak concentration 03 medical and health sciences 0302 clinical medicine Lag time Hypothermia Induced medicine Journal Article Humans Coma Blood Coagulation Aged business.industry Thrombin 030208 emergency & critical care medicine Middle Aged Hypothermia Cardiopulmonary Resuscitation Thrombelastography Clinical trial Thromboelastometry Anesthesia Emergency Medicine Time to peak Female medicine.symptom Cardiology and Cardiovascular Medicine business Out-of-Hospital Cardiac Arrest |
| Zdroj: | Jeppesen, A N, Hvas, A-M, Duez, C H V, Grejs, A M, Ilkjær, S & Kirkegaard, H 2017, ' Prolonged targeted temperature management compromises thrombin generation : A randomised clinical trial ', Resuscitation, vol. 118 . https://doi.org/10.1016/j.resuscitation.2017.06.004 |
| DOI: | 10.1016/j.resuscitation.2017.06.004 |
| Popis: | AIM: To investigate whether prolonged compared with standard duration of targeted temperature management (TTM) compromises coagulation.METHODS: Comatose survivors after out-of-hospital cardiac arrest (n=82) were randomised to standard (24h) or prolonged (48h) duration of TTM at 33±1°C. Blood samples were drawn 22, 46 and 70h after attaining the target temperature. Samples were analysed for rotational thromboelastometry (ROTEM(®) (EXTEM(®), INTEM(®), FIBTEM(®) and HEPTEM(®))) and thrombin generation using the Calibrated Automated Thrombogram(®) assay.RESULTS: With the 22-h sample, we revealed no difference between groups in the ROTEM(®) and thrombin generation results beside a slightly higher EXTEM(®) and INTEM(®) maximum velocity in the prolonged group (p-values≤0.04). With the 46-h sample, ROTEM(®) showed no differences when using EXTEM(®); however, 11% (pCONCLUSION: Prolonged TTM in post-cardiac arrest patients impairs thrombin generation. ClinicalTrials.gov identifier: NCT02258360. |
| Databáze: | OpenAIRE |
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