Prospective Evaluation of Brush Cytology of Biliary Strictures During Endoscopic Retrograde Cholangiopancreatography
| Autor: | Bernd Glasbrenner, M. Ardan, P. Möller, W. Boeck, G. Preclik, G. Adler |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Male medicine.medical_specialty Biopsy Malignancy Sensitivity and Specificity Gastroenterology Cholangiocarcinoma Diagnosis Differential Cholestasis Bile Ducts Extrahepatic Internal medicine medicine Humans Aged Aged 80 and over Cholangiopancreatography Endoscopic Retrograde Endoscopic retrograde cholangiopancreatography medicine.diagnostic_test business.industry Cholestasis Extrahepatic Middle Aged medicine.disease Endoscopy Pancreatic Neoplasms Bile Duct Neoplasms Dysplasia Biliary tract Pancreatitis Female business |
| Zdroj: | Endoscopy. 31:712-717 |
| ISSN: | 1438-8812 0013-726X |
| Popis: | Background and Study Aims: Cytological methods may be used to differentiate benign from malignant biliary strictures. We evaluated the diagnostic accuracy of an endobiliary cytotechnique which can easily be performed during endoscopic retrograde cholangiopancreatography. Patients and Methods: Cytological samples were obtained by brushing biliary strictures via a guide wire in 86 patients with strictures of unknown status. Samples were classified by an expert cytologist as normal (including reactive cells), severely dysplastic (atypical cells suspicious of malignancy) and clearly malignant. A final diagnosis was achieved in 78 patients based on intraoperative findings and histological investigation, autopsy or prolonged follow-up. Strictures were malignant in 57 cases (31 pancreatic carcinoma, 20 cholangiocarcinoma, 6 others) and benign in 21 cases (11 chronic pancreatitis, 5 chronic nonspecific inflammation, 5 others). Results: The overall results for brush cytological investigation were sensitivity 56.1 %, specificity 90.5 %, positive predictive value 94.1 %, negative predictive value 43.2 %, and accuracy 65.4 %. Sensitivity was significantly higher (P |
| Databáze: | OpenAIRE |
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