Streptozotocin causes pancreatic beta cell failure via early and sustained biochemical and cellular alterations
| Autor: | Ernest Adeghate, Rasheed Hameed, Donáth T, Saeed Tariq, Rajan Sheen, A. S. Ponery, Shaffiullah M |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors endocrine system diseases Epinephrine Endocrinology Diabetes and Metabolism In Vitro Techniques Hypoinsulinemia Cell Degranulation Streptozocin Diabetes Mellitus Experimental Norepinephrine Endocrinology Internal medicine Diabetes mellitus Insulin-Secreting Cells Insulin Secretion Weight Loss Internal Medicine medicine Animals Insulin Rats Wistar Pancreas geography geography.geographical_feature_category business.industry Secretory Vesicles Osmolar Concentration Degranulation nutritional and metabolic diseases General Medicine Hydroxyindoleacetic Acid medicine.disease Streptozotocin Islet Glucagon Rats medicine.anatomical_structure Hyperglycemia Catecholamine Beta cell business medicine.drug |
| Zdroj: | Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 118(10) |
| ISSN: | 1439-3646 |
| Popis: | The morphological and biochemical changes that occur in the early phase of streptozotocin (STZ)-induced beta cell failure have not been characterized. The pancreas and plasma of rats treated with STZ were processed for morphological and biochemical parameters 1-24 h and 4 weeks after STZ treatment. Marked reduction in body weight was observed as early as 3 h post STZ treatment and hyperglycemia coupled with hypoinsulinaemia appeared in rats 1 h after treatment with STZ. Hyperglycemia, hyperglucagonemia and hypoinsulinemia became permanent 24 h after STZ treatment. The number of insulin-positive cells decreased significantly (p |
| Databáze: | OpenAIRE |
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