Response to a single oral dose of all-rac-alpha-tocopheryl acetate in patients with cystic fibrosis and in healthy individuals
| Autor: | B.M. Winklhofer-Roob, P Tuchschmid, D.H. Shmerling, Luciano Molinari |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Erythrocytes Pancreatic disease Cystic Fibrosis medicine.medical_treatment alpha-Tocopherol Administration Oral Tocopherols Medicine (miscellaneous) Pancreatic Extracts Cystic fibrosis Antioxidants Absorption chemistry.chemical_compound Internal medicine medicine Humans Vitamin E Vitamin E Deficiency Child Exocrine pancreatic insufficiency Nutrition and Dietetics Dose-Response Relationship Drug Pancrelipase business.industry Cholesterol Biological Transport Lipase medicine.disease Lipids Endocrinology chemistry Female Vitamin E deficiency Tocopheryl acetate business |
| Zdroj: | The American Journal of Clinical Nutrition. 63:717-721 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/63.5.717 |
| Popis: | Biochemical vitamin E deficiency and low plasma lipids are frequent findings in patients with cystic fibrosis (CF). The response to a single oral dose of all-rac-alpha-tocopheryl acetate [100 IU (100 mg)/kg body wt] was studied over 24 h in 25 CF patients with exocrine pancreatic insufficiency and in 23 healthy individuals. Patients received pancreatic enzymes together with the vitamin E test dose. At baseline, plasma alpha-tocopherol concentrations correlated with cholesterol concentrations; both were lower in patients than in control subjects, as were erythrocyte alpha-tocopherol concentrations (all P < 0.0001). Plasma and erythrocyte alpha-tocopherol concentrations were significantly higher than baseline concentrations from 3 and 6 h onward, respectively, and peaked most frequently at 6 and 12 h, respectively, in both patients and control subjects. Maximum increases and areas under the concentration time curves for plasma alpha-tocopherol concentrations were smaller in patients than in control subjects (P < 0.0001). When ratios of plasma alpha-tocopherol to cholesterol (to correct for differences in cholesterol concentrations) or erythrocyte alpha-tocopherol concentrations were applied, patients were shown to respond as efficiently as control subjects. On the basis of these results, we recommend vitamin E supplements in doses high enough to achieve vitamin E status in CF patients well within the range of healthy individuals; these supplements should be given with appropriate amounts of pancreatic enzymes. However, for long-term supplementation much lower doses than those used in this test situation may be sufficient. |
| Databáze: | OpenAIRE |
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