Innate Immune Responses and Viral-Induced Neurologic Disease
| Autor: | Thomas E. Lane, Dominic D Skinner, Yuting Cheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Multiple Sclerosis Clinical Sciences Central nervous system lcsh:Medicine Disease Review virus Neurodegenerative Autoimmune Disease 03 medical and health sciences 0302 clinical medicine neutrophils Demyelinating disease medicine 2.1 Biological and endogenous factors Aetiology Remyelination innate immunity Neuroinflammation Innate immune system business.industry Inflammatory and immune system Multiple sclerosis lcsh:R Neurosciences General Medicine Stem Cell Research medicine.disease Acquired immune system Brain Disorders 3. Good health 030104 developmental biology medicine.anatomical_structure remyelination Neurological Immunology Stem Cell Research - Nonembryonic - Non-Human demyelination business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Medicine, Vol 8, Iss 1, p 3 (2018) Journal of Clinical Medicine Journal of clinical medicine, vol 8, iss 1 |
| ISSN: | 2077-0383 |
| Popis: | Multiple sclerosis (MS) is a disease of the central nervous system (CNS) characterized by chronic neuroinflammation, axonal damage, and demyelination. Cellular components of the adaptive immune response are viewed as important in initiating formation of demyelinating lesions in MS patients. This notion is supported by preclinical animal models, genome-wide association studies (GWAS), as well as approved disease modifying therapies (DMTs) that suppress clinical relapse and are designed to impede infiltration of activated lymphocytes into the CNS. Nonetheless, emerging evidence demonstrates that the innate immune response e.g., neutrophils can amplify white matter damage through a variety of different mechanisms. Indeed, using a model of coronavirus-induced neurologic disease, we have demonstrated that sustained neutrophil infiltration into the CNS of infected animals correlates with increased demyelination. This brief review highlights recent evidence arguing that targeting the innate immune response may offer new therapeutic avenues for treatment of demyelinating disease including MS. |
| Databáze: | OpenAIRE |
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