Use of antiviral therapy in patients with chronic hepatitis C
| Autor: | Walery Zukow, Mariusz Klimczyk, Anna Izha, Mirosława Szark-Eckardt, Krzysztof Prusik, Radosław Muszkieta, Marek Napierała, Natalia Dragomiretskaya, Nikolay Kalinichenko, Hanna Żukowska, Mirosława Cieślicka |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
business.industry Hepatitis C virus Antiviral therapy health resort factors General Medicine Disease medicine.disease_cause medicine.disease Gastroenterology Virus law.invention Cholestasis law Internal medicine medicine chronic hepatitis C Medicine business Genotyping Polymerase chain reaction Depression (differential diagnoses) Research Article |
| Zdroj: | Open Medicine, Vol 10, Iss 1 (2015) Open Medicine |
| ISSN: | 2391-5463 |
| Popis: | Introduction: The presence of background HCV infection cannot be overestimated in view of the prevalence of chronic hepatitis C and the risk of adverse outcomes of this disease. Purpose of this study was to evaluate the effectiveness of the combined use of antiviral therapy (Roferon + Vero-Ribavirin) and resort factors in patients with chronic hepatitis C in the phase of replication. Material and methods: We observed 48 patients with chronic hepatitis C; the minimum level of activity of the process defined the phase of replication. Markers of HCV infection were determined by enzyme linked immunosorbent assay (ELISA) (a-HCV and HCV-Ig M). HCV RNA was determined twice by the polymerase chain reaction (PCR). Genotyping of hepatitis C virus was performed. Biochemical blood analysis and the study of HCV infection markers were carried out four times. Results of therapy were assessed immediately after the end of the resort (spa) treatment, then at 3, 6 and 12 months after starting treatment. At 12 months after starting treatment, all the observed patients had persistent clinical and biochemical remission. Elimination of the virus from the blood was noted in 56% of the control group and 74% of patients in the study group. Conclusions: For patients with moderately active HCV, the replication phase was characterized by asthenic-vegetative syndrome (100% of patients) with severe depression (22.92%), pain (77.08%) and dyspeptic syndrome (33.33%), moderate hypertransferaseemia (100%), slightly pronounced cholestasis (33% of patients), and signs of mesenchymal- inflammatory response. |
| Databáze: | OpenAIRE |
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